Pro-Active Collagen ADVANCED
Pro-active® ADVANCED is a premium liquid collagen supplement formulated to support overall wellness and healthy aging. At its core is the high-quality Fortigel® B, bioactive collagen peptides derived from bovine, clinically tested for the high bioavailability, absorption, and effectiveness in supporting collagen regeneration in cartilage tissues, joint health, and skin hydration.
The formula contains 11 active ingredients carefully selected to support collagen regeneration by the human body: Silicon (orthosilicic acid) plays a key role in collagen formation, Hyaluronic acid that supports skin hydration and plumpness, promoting a smoother and youthful appearance, Magnesium an important mineral to support collagen production, muscle function, and helps reduce fatigue and Zinc a vital mineral that plays a central role in collagen synthesis and joint health.
A carefully balanced blend of essential nutrients complements the formula: Vitamin C plays a key role in collagen formation, and Vitamin D3 contributes to the maintenance of normal bones, joints, and immune system function, and B-complex vitamins - B1 (thiamine), B2 (Riboflavin), B5 (pantothenic acid) and B6 (Pyridoxine Hydrochloride) - play important roles in energy metabolism, nervous system support, and overall vitality.
Why is Collagen ProActive different?
A medical-grade, high-strength liquid formulation designed for real absorption and visible results
Why liquid collagen works better than capsules or powders:
1. Faster absorption
Liquid collagen is already dissolved and hydrolysed (broken down)
This means:
- Your body doesn’t need to break it down first
- It moves through digestion faster
- It becomes available for use more quickly
Capsules & powders:
- Must first dissolve and break down
- Slower process before absorption begins and not at the correct dosage.
2. Higher usable absorption (bioavailability)
It’s not just what you take , it’s what your body can use.
Liquid formats allow for:
- More efficient uptake in the digestive system
- Less loss during breakdown
Result: More collagen peptides available to support your body and show results.
3. Effective dosing is easier
To get a meaningful dose (like 10,000mg):
Capsules:
- You’d need multiple capsules daily
- Lower compliance
Liquid:
- One measured dose
- Easy, consistent daily use
Consistency = results
4. Better delivery of added ingredients
Liquid formulas can include:
- Vitamins
- Minerals
- Co-factors
These help:
- Stimulate collagen production
- Support skin, hair, and joints
Capsules often have limited space, so formulations are simpler and less comprehensive.
Designed for results, not convenience
5. Why 10,000mg matters
10,000mg is a high-strength, results-driven dose, not just maintenance.
It delivers the level your body needs to actively support skin firmness, hair strength, and structural repair from within.
6. Advanced formulation, not just collagen
More than just collagen , an advanced formulation designed to support collagen production, improve absorption, and enhance visible results across skin, hair, and overall tissue health.
Pro-Active Collagen ADVANCED Liquid Collagen is a unique Medical Grade dietary supplement of premium quality Hydrolyzed Collagen, derived from Bovine, enhanced with Hyaluronic Acid, Vitamin C, Silicon, Zinc Vitamin D3, Vitamins B1, B2, B5, B6 and Magnesium. This superior formulation is easily absorbed by the human body, with proven >90% bioavailability.
- For women & men
- Hydrolyzed Collagen (Type I) of high quality, enhanced with Vitamins C, B1, B2, B5, B6, Hyaluronic Acid, Magnesium, Zinc and Silicon
- With a very high percentage of oral absorption (more than 90%¹,²)
- Available in two delicious flavours: Strawberry & Lemon
- Fat-free
- Up to date, no known contraindications or side effects
Quality. Certified. Trusted
Collagen ProActive is manufactured to the highest international standards and trusted across global markets
Award-Winning Excellence
Recognised as Top Nutritional Supplement Producer and Distributor in Europe – 2025
(Pharmacros)
Global Certifications & Registrations
- FDA registration processed
- Registered in EU & Africa
(Spain, Greece, Cyprus, Romania, Bulgaria, South Africa) - Halal Certified
Pro-Active Collagen ADVANCED Composition:
| Active Ingredients | Per 25ml | % RDA** |
| Hydrolyzed Collagen* | 10 000 mg | N/A |
| Magnesium | 60 mg | 16% |
| Vitamin Β5 (Dexpanthenol) | 6.00 mg | 100% |
| Vitamin Β2 (Riboflavin) | 1.40 mg | 100% |
| Vitamin Β6 (Pyridoxine Hydrochloride) | 1.40 mg | 100% |
| Vitamin Β1 (Thiamine Hydrochloride) | 1.10 mg | 100% |
| Vitamin C | 80 mg | 100% |
| Hyaluronic Acid | 20 mg | N/A |
| Zinc | 10 mg | 100% |
| Silicon | 5 mg | N/A |
| *Bovine (beef) Originated | **RDA=Recommended Daily Allowance | |
Pro-Active Collagen ADVANCED Active Ingredients:
Vitamin C is proven to:
- Be strong antioxidant
- Reduce risk for cardiovascular disease, and stroke
- Boost immune system
- Protect indispensable molecules in the body such as proteins, lipids, carbohydrates, and nucleic acids (DNA, RNA)
- Contribute to the formation of collagen and several other critical biomolecules
Hyaluronic Acid is proven to:
- Promote stronger, more supple skin
- Speed up wound healing
- Relieve Joint Pain by keeping joints well lubricated
- Soothe acid reflux symptoms
- Preserve bone strength
Magnesium (Mg) assists with:
- A reduction of tiredness and fatigue
- Electrolyte balance
- Normal energy yielding metabolism
- Normal functioning of the nervous system
- Normal muscle function / neurotransmission and muscle contraction including heart muscle
- Normal protein synthesis
- Normal psychological function
- The maintenance of normal bones
- The maintenance of normal teeth
- The process of cell division
Zinc (Zn):
A daily intake of zinc is required to maintain a steady state because the body has no specialized zinc storage system involved in cellular metabolism It is required for the catalytic activity of approximately 100 enzymes.
- Plays a role in immune function
- Plays a significant role in protein synthesis
- Plays a role in wound healing
- Plays significant role DNA synthesis and cell division
- inc also supports a normal growth and development and supports proper sense of taste and smell
Silicon (Si):
- Acts as a stabilizing force in the body. It restores the necessary balance between calcium and magnesium, thus maintains normal hormone function
- It stabilizes a number of structures, including bodily tissues, membranes and arterial walls
- Helps in producing collagen
- It facilitates your body’s absorption of calcium, contributing to strong, healthy bones.
- Silicon works together with sulfur to give your skin and nails a youthful, healthy appearance
- Boost the immune system
- Helps preventing CVD by keeping theartery walls flexible
- Helps against hair loss
Vitamin B1 (Thiamine):
- Normal energy yielding metabolism
- Normal functioning of the nervous system
- Normal psychological functions
- Normal function of the heart
Vitamin B2 (Riboflavin):
- Normal energy yielding metabolism
- Normal functioning of the nervous system
- The maintenance of normal skin
- The maintenance of normal red blood cells
- The maintenance of normal mucous membranes
- The maintenance of normal vision
- The normal metabolism of iron
- The protection of cells from oxidative stress / protection of DNA, proteins and lipids from oxidative damage
- The reduction of tiredness and fatigue
Vitamin B5 (Pantothenic Acid):
- Normal energy yielding metabolism
- Normal mental performance
- Normal synthesis and metabolism of steroid hormones, vitamin D and some neurotransmitters
- The reduction of tiredness and fatigue
Vitamin B6 (Pyridoxine):
- Normal cysteine synthesis
- Normal energy yielding metabolism
- Normal functioning of the nervous system
- Normal homocysteine metabolism
- Normal protein and glycogen metabolism
- Normal psychological function
- Normal red blood cell formation
- Normal function of the immune system
- The reduction of tiredness and fatigue
- The regulation of hormonal activity
Simple. Daily. Effective:
Daily Dosage:
Take one measuring cup daily, (20 – 25ml), as is, or diluted in water or juice.
Preferably in the evening. Shake well before use.
Store below 25°C, away from direct light. Not in Fridge.
Keep out of reach of children.
Consult your doctor if you have any medical conditions.
Production quality
Pro-active® ADVANCED is produced under strict Pharmaceutical-grade production standards. The manufacturing site, located in France, is certified by ANSM under GMP (Good Manufacturing Practices) to produce liquid medicines. Following a unique manufacturing process, specifically designed to respect all active ingredients' properties and characteristics, Pro-active® ADVANCED production quality meets the highest standards, which include advanced quality control systems and precise ingredient sourcing with full traceability. Every stage of production - from raw material testing to final product packaging - is carefully monitored to ensure purity, potency, safety, and efficacy. Contaminants such as heavy metals, microbes, and impurities are meticulously screened and eliminated. This elevated standard guarantees consistent dosage accuracy and bioavailability, offering consumers a level of reliability and trust that surpasses conventional supplement manufacturing.
Product quality assurance
Focusing on the uncompromising finished product quality to assure product efficacy during the shelf life, Pro-active® ADVANCED has been successfully tested for its formula stability and for preservative efficacy:
Stability Test: A six-month accelerated stability test, conducted in accordance with International Council for Harmonization (ICH) guidelines, designed to evaluate the durability and quality of a product under intensified environmental conditions. Performed at elevated temperature and humidity levels of 40°C and 75% relative humidity, this study simulates long-term storage in a shorter timeframe. Throughout the testing period, critical parameters - including physical appearance, pH, microbiological integrity, and active ingredient potency - are regularly monitored. Successful results provide valuable insight into the product’s shelf life, packaging suitability, and formulation robustness, ensuring that the Pro-active ADVANCED maintains its safety, efficacy, and quality over time.
Challenge Test: Pro-active® ADVANCED has been successfully evaluated by an “Efficacy of preservative testing” in accordance with the standards of the European Pharmacopoeia, ensuring a high level of product safety and microbiological stability. This test assesses the ability of the formulation’s preservative system to inhibit the growth of microorganisms introduced under controlled conditions. During the study, the Pro-active® ADVANCED formula has been intentionally inoculated with specific strains of bacteria, yeasts, and molds defined by the pharmacopoeia guidelines. Microbial counts have been measured at predetermined intervals to confirm a significant reduction over time. To meet compliance, the preservative system must demonstrate rapid and sustained antimicrobial activity, preventing contamination throughout the product’s intended shelf life.
In addition, each production is thoroughly tested both during and after its completion for the quality of the finished product, with extensive quality controls in GMP-certified laboratories following the European Pharmacopoeia standards before released to the markets.
Adherence to these rigorous European standards ensures Pro-active® ADVANCED remains safe, stable, and protected against microbial proliferation, reinforcing both product quality and consumer trust.
Key Benefits
- Support Collagen regeneration
- Promote Cartilage
- Regeneration
- Preserve Mobility
- Improve Joint Flexibility
- Enhance Skin Hydration and Elasticity
- Promote Optimal Wellness and Radiant Skin
- High Bioavailability andAbsorption
Product characteristics
- Primary Packaging: 600 ml PET bottle, closing cap with safety, and measuring cup
- Daily Dose: 25 ml
- Packaging Servings: 24 daily doses
- Flavors: Strawberry / Lemon
- Collagen per Serving: 10.000 mg
- Collagen Peptides origin: Bovine, Fortigel® B, by Gelita AG
- Active Ingredients: Silicon, Hyaluronic Acid, Vitamin C, Vitamin D3, Magnesium, Zinc, Vitamin B1, B2, B5, and B6
- GLUTEN Free, FAT Free, GMO Free, Clean label product
- HALAL Certified: Pro-active® ADVANCED is certified with Halal certificate for the finished product by the Islamic Center of Aachen, Germany
FAQs
What is Collagen?
Collagen is a key component of the basic structures of the human body and the connective tissue. It is an abundant protein of the body, accounting for about 30% of total body protein and 75% of the protein that makes up skin. As a result, collagen is the main constituent of our skin.
Collagen plays a leading role in all body functions since it is responsible for:
- The outer body (skin and hair)
- The flexibility & mobility of the body’s structural components (cartilages & joints)
- The smooth functioning of internal organs
- The maintenance of good form for blood vessels and bone density
Collagen’s role in the skin’s structure:
Common structural property of collagen is the presence of three polypeptide chains, that form a helix. A single collagen fiber comprises of multiple triple helices. There are several types of collagen in the human body. The most common are Types I, II & III, which are found in skin, tendons, joints, cartilages & blood vessels.
As we age, our organism tends to produce less collagen at a declining rate of about 1,5% per year from the age of 25 onwards. As a result, bones lose density, joints become more rigid, hair volume decreases, skin elasticity lessens and muscles weaken. The number and activity of skin cells (fibroblasts), that produce collagen, decreases. As fibroblasts become less active, the collagen matrix which provides skin firmness and structure, starts to break down. Skin then becomes dehydrated and thinner, plus, fine lines, wrinkles and deep furrows start to appear.
So, what can we do to replace collagen in our organism? Since sufficient quantity of Collagen cannot be provided through the consumption of different kind of food, therefore the intake of Collagen is essential.
What is Hydrolyzed Collagen?
Hydrolyzed collagen, which is the leading form of collagen, is produced through the process of enzymatic hydrolysis of collagen protein. The process of hydrolysis involves breaking down the molecular bonds between individual collagen strands using combinations of enzymes. This process doesn’t use heat, chemicals or acids, but rather collagen is dissolved in water. The hydrolysis process results in reducing the collagen proteins of about 300,000 Da into small peptides having an average molecular weight between 2000 and 5000 Da.
Clinical studies have shown that the percentage of bioavailability is more than 90%¹,². Oral administration of hydrolyzed collagen is absorbed within the first 12 hours from the intake.
Hydrolyzed collagen contains 20 amino acids, which together represent around 50% of the total amino acid content.
Hydrolyzed Collagen’s peptides contain three times higher amount of proline, glycine and hydroxyproline amino acids. These amino acids are essential for the synthesis of new collagen and they strengthen the stability of collagen’s structure in the body.
| Amino acids | Percentage (%) |
| Proline/Hydroxyproline | 25% |
| Glycine | 20% |
| Glutamic acid | 11% |
| Alanine | 8% |
| Arginine | 8% |
| Other essential amino acids | 16% |
| Other non-essential amino acids | 12% |
Competitive Advantages of Hydrolyzed Collagen:
Because of its low molecular weight, hydrolyzed collagen presents some advantages when used compared to the natural / normal collagen:
- Dissolves in cold water
- Highly digestible (more than 90%¹,² bioavailability)
- Easily absorbable and can be distributed throughout the human body.
Stimulation of collagen in the body has a positive impact on our wellness by revealing a youthful, vibrant, fresh and vital inner beauty!!!
Beneficial Properties
Medical Grade Pro-Active Collagen ADVANCED’s benefits for Wellness:
For Joints
Medical Grade Pro-Active Collagen ADVANCED is a unique dietary supplement enriched with magnesium, and a vitamin B complex that helps individuals who suffer from joint pain.
- Provides a powerful antioxidant action(19)
- Activates energy production in the organism through
- Magnesium and Vitamins B5, B2, B6 & B1
- Contributes to the reduction of tiredness and fatigue through Magnesium and Vitamins B5, B2 & B6
- Contributes to decrease joint rigidity and mobility pain(3)
- Contributes to increase the articular cartilage thickness of joints(4)
- Contributes to increase the cartilage mass(4)
- Contributes to the normal function of bones through development and growth(11)
- Assists in the improvement of Osteoarthritis and Osteoporosis(10)(11)(12)(17)
- Promotes a normal function of the cardiovascular & nervous system through Magnesium and Vitamins B2, B6 & B1
- Affect the size of the collagen fibrils in the tendon & may improve the mechanical properties of the tendon(9)
- Contributes to normal psychological function & mental performance, while providing “anti-stress” properties through Vitamin B1
- Maintains strong teeth and gums through Magnesium
Medical Grade Pro-Active Collagen ADVANCED’s benefits in Beauty:
For Hair
Medical Grade Pro-Active Collagen ADVANCED provides benefits for the hair as well. It is clinically proven that the hydrolyzed collagen in Medical Grade Pro-Active Collagen ADVANCED enhances hair strength and appearance.
For Skin
Medical Grade Pro-Active Collagen ADVANCED increases the density of the fibers and fibroblasts, which are the principal cells of the skin and are responsible for the production of collagen. Medical Grade Pro-Active Collagen ADVANCED once absorbed by the small intestine is distributed from the arteries to the deepest layer of the skin, leading to fibroblast proliferation and increased collagen production. With daily use of Medical Grade Pro-Active Collagen ADVANCED, the skin becomes more hydrated.
- Enhances skin beauty
- Contributes to the maintenance of normal skin tonicity
- Contributes to the maintenance of skin elasticity & hydration(6)
- May help to fight against the visible signs of skin aging
- Contribute to the stimulatory effect of the Collagen biosynthesis in the body tissue(13)
- May function as a stimuli for fibroblasts to effect repair of damaged tissue(8)
- Improves skin’s dryness(5)
- Enhances hair strength and appearance from 5% to 45% (7)
Medical Grade Pro-Active Collagen’s benefits in Sport:
For Sport
Collagen is an excellent form of protein as it contains 8 out of the 9 basic amino acids. Intense exercise destroys protein in the body making their replacement very important. Medical Grade Pro-Active Collagen ADVANCED also contains glycine and arginine that play an important role during exercise, providing energy to the body and thus improving athletic performance. In addition, hydrolyzed collagen contributes significantly to the rapid restoration of tissue, ligaments and cartilage, and muscle post injury.
- Contributes to the normal muscle function through maintenance and growth through Collagen Protein Magnesium
- Promotes much easier sport and recreational activity(3)
- Reduces the risk of joint & cartilage injury and supports recovery time after physical activity(4)
- Assists in the normal metabolism of fat and protein in the organism, while supporting active nutrition through Magnesium and Vitamins B5, B2, B6 & B1
- Maintains a healthy digestive tract (14)(15)(16)
Testimonials
Collagen ProActive Testimonials
Please share your story with us. Email to: joannehayward@proactivesa.co.za – Thank you.
Its been the whole wellness package for me – I am a Runner and I feel stronger, my joints dont ache and my injuries are so much less – I am hooked!
Joshua
Ageing comes to us all, but my skin is now firmer and smoother – I feel younger! Its such a great feeling!
Dawn
I had given up on losing my hair! I have tried everything. After a few months now on Collagen pro-Active, my hair is growing so well, and looks healthy and strong!
James
The Arthritis in my hands was so bad – i couldnt even open a jar! Now after using Collagen Pro-Active, I have my hands back! No more pain and the swelling has gone! I cant believe it!
Pam
Collagen Pro-Active has been used in conjunction with splinting and hand therapy to heal my dislocating thumb CMC joint and base of thumb Arthritis. I now have full functional use of my thumb without the need for a splint and without any pain. I have also noticed that my hair and nails are growing much faster. I am extremely satisfied with the results.
Lebogang Monaisa
My joints dont ache anymore, I can do things I havent been able to for ages! Thank you!
Diana
I have been using CP for the last year and love the product immensely ! I felt a difference in my energy levels and skin within the first 3 weeks of using it.
The condition of my skin and hair has improved drastically over the last year where people started to notice the difference.
I have gained lean muscle mass over the last few months as this product helps with muscle recovery, which increases the intensity level of my training sessions.
CP became part of my beauty and health regime and personally feel it’s more important to spend money on a product that works from the inside out than expensive external products.
Carla
I can’t stop raving! Like most people, when I was a young adult I thought nothing could harm me, but then life happened. For more than 30 years my shoulders and elbows have ached, all have had surgery performed on them, and although the surgery fixed part of the problem, cartilage wear and tear and tendon tears took their toll. When I started to investigate Collagen Proactive, I discovered that it is registered by the FDA in the United States as a Cartilage regenerative. Something no other Collagen has achieved. I started taking Collagen Proactive in September, 2015, within two weeks I was pain free and now 6 months later I am still pain free, and my shoulders feel much easier to move. What a brilliant product. I tried the other Collagens but nothing worked like Proactive, Thank you for bringing it into South Africa. Everyone should be on it.
Brian
I am feeling great! I am a Runner and my knees don’t ache anymore, I can run longer and faster – thank you!! I will never stop this amazing product!
Angie
I bought this product for my wife and she has been very happy with it. She feels more energetic and can see a difference in her skin and nails.
Mario Finto
What is the recommended daily dose and when should I intake Medical Grade Pro-Active Collagen ADVANCED?
A measuring cup per day diluted in a glass of water or juice, is recommended, preferably before evening sleep. Shake well before each use. Store in a cool and dry place, away from direct light and below 25°C.
Does Medical Grade Pro-Active Collagen ADVANCED have any side effects?
No side effects or contraindications have been noted so far.
Consumers with Allergies and/or any other medical issue should consult their doctor before consuming this product. Product does not contain any ingredients according to Directive 2013/13/EC & amendments and it is GMO Free.
What does it taste like?
Medical Grade Pro-Active Collagen ADVANCED is available in two delicious flavours, lemon and strawberry.
When do I get to see the first results?
Most people respond positively to the product even before consuming the first bottle, that is about a month or soon after the beginning of the second month of product use and results in such a few days are amazing. However, not all individuals have the same results at the same time period since there are many factors that affect the wellness of the skin such as genes, lifestyle, diet, extensive sun exposure, smoking, etc. In order to get best results 20ml daily – continuous use is recommended for optimal benefit. As we continue to lose 1,5% of our Collagen per year from age 25 – continued use is recommended.
How does Medical Grade Pro-Active Collagen ADVANCED work?
The enzymes in our stomach breaks the hydrolyzed collagen down into smaller peptides and free amino acids which are then easily absorbed in the small intestine before passing through the small intestine walls to reach the blood stream supplying the dermis & the body. Then, they activate the fibroblast cells to make new collagen.
Why is Medical Grade Pro-Active Collagen ADVANCED superior to an average anti-wrinkle cream?
Pro-Active Collagen ADVANCED stimulates the cells responsible for the body’s own natural production of collagen. It works in the deeper layer of the skin (dermis) and all over the body, whereas creams are more localized in one area on the outer layer of the skin (epidermis).
What is the effect of Medical Grade Pro-Active Collagen ADVANCED on cosmetic dermatology procedures?
Pro-Active Collagen ADVANCED is not invasive and therefore acts complementary. As a dietary supplement, Pro-Active Collagen ADVANCED is noninvasive way to improve skin’s appearance with excellent results.
Are there clinical trials that describe the way the product works?
Numerous scientific clinical studies have been conducted on the benefits of the finished product but also on the active ingredient, collagen peptides/hydrolyzed collagen. See Clinical Studies